The left DTI-ALPS index: a potential glymphatic mediator of cognitive and motor dysfunction in Parkinson's disease.

ABSTRACT:

Introduction

This study employed the Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) index to evaluate glymphatic function in patients with Parkinson's disease (PD) and investigated its association with cognitive and motor functions.

Methods

Clinical data from the PD group (n = 64) and the healthy control group (HC, n = 30), matched for age, sex, and education years, were included. Based on Montreal Cognitive Assessment (MoCA) scale, PD patients were further categorized into subgroups. All participants underwent DTI scan and scale assessments.

Results

Compared with the HC group, the PD group exhibited increased diffusivity of both the left projection (Dzzproj) and association fibers (Dzzassoc) along the z-axis (p < 0.05) an

SUBMITTER: Li Y 

PROVIDER: S-EPMC12698549 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature