Structural and genomic insights into erythromycin and clindamycin resistance of group B <i>Streptococcus</i> isolates in rural West Virginia, United States.

ABSTRACT:

Introduction

Group B Streptococcus (GBS) is a leading etiological agent of neonatal sepsis and meningitis, as well as invasive infections that predominately affect adults over 65 and people with comorbidities. The Centers for Disease Control and Prevention's (CDC) nationwide surveillance has identified rising clindamycin and erythromycin resistance as a concerning level threat for invasive GBS infections. West Virginia (WV) is a rural state outside the CDC catchment area, therefore, we investigated 65 WV-GBS isolates identified in clinical specimens from various sources for serotype distribution, as well as the spectrum and genetic markers of erythromycin and clindamycin resistance.

Results

GBS isolates of serotypes II (27.7%), Ib (23.1%), V (18.5%), Ia (13.8%), III (

SUBMITTER: Smith AP 

PROVIDER: S-EPMC12698558 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature