Effect of liraglutide on the dysglycemia, inflammation, and gut microbiota in prediabetic KKay mice.

ABSTRACT: Prediabetes is a significant risk factor for type 2 diabetes mellitus (T2DM). Emerging evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1RAs) may modulate the gut microbiota and improve dysglycemia in T2DM. In this study, we investigated the effects of liraglutide on dysglycemia and gut microbiota in prediabetic mice. KKay mice were fed a high-fat diet to establish prediabetes. The prediabetic mice were then treated with a daily intraperitoneal injection of liraglutide for 12 weeks. 16S rDNA sequencing was employed to investigate alterations in the gut microbiota in prediabetic mice and liraglutide-treated prediabetic mice. The gut bacterial metabolites in the ileal contents of prediabetic mice were measured via a liquid chromatography‒mass spectrometry (LC‒MS) system.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12698571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature