Longitudinal TyG-BMI trajectories predict carotid atherosclerosis progression in a Chinese retrospective cohort.

ABSTRACT:

Background

Carotid atherosclerosis (CAS) is a major precursor of ischemic stroke, underscoring the importance of early identification of reliable metabolic risk markers. Insulin resistance and metabolic dysfunction are recognized as key contributors to CAS development, and the triglyceride-glucose body mass index (TyG-BMI) has emerged as a promising surrogate biomarker.

Methods

In this retrospective cohort study, we analyzed 2,329 Chinese adults who underwent serial health examinations, with a median follow-up of 1,826 days. Using latent class trajectory modeling, two distinct TyG-BMI trajectories were identified: stable (Class 1) and rising (Class 2).

Results

CAS progression was observed in 46% of participants, with a higher incidence in the rising trajectory group (

SUBMITTER: Wang C 

PROVIDER: S-EPMC12698576 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature