Circulating prostaglandin E₂ concentrations decrease at birth in premature lambs.

ABSTRACT:

Rationale

During pregnancy, prostaglandin E₂ (PGE₂) is released from the placenta and circulates in relatively high concentrations in the fetus. As PGE₂ suppresses breathing, PGE₂ concentrations must decrease after birth, but the timing and mechanisms behind this decrease are unknown. We hypothesised that both umbilical cord clamping and lung aeration contribute to the reduction in PGE₂ concentrations after birth.

Materials and methods

Instrumented premature lambs (138-141 days gestation) were randomised to receive either physiological-based cord clamping (PBCC; cord clamping after ventilation onset; n = 5) or immediate cord clamping (ICC; before ventilation onset; n = 6). PGE₂ concentrations wer

SUBMITTER: Panneflek TJR 

PROVIDER: S-EPMC12698598 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature