Perceived quality of life, fatigue and the metabolic cost of walking in generalized hypermobility spectrum disorder and hypermobile Ehlers-Danlos syndrome.

ABSTRACT:

Introduction

Individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) often experience chronic pain, leg fatigue and/or pain, which may contribute to a higher metabolic cost of walking. How these subjective measures may manifest in an elevated metabolic cost of transport and perceived pain at varying walking speeds remains to be evaluated.

Methods

We recruited 11 HSD/hEDS participants (33 ± 14 yrs, 170 ± 6. cm, weight 71 ± 11 kg) and 11 age- and sex-matched controls. Self-reported subjective outcome measures of health-related quality of life, fatigue severity, and foot function were evaluated prior to treadmill walking using the 36-Item Short Form Health Survey (SF-36) and the Fatigue Severity Scale (FSS). Participants also rated

SUBMITTER: Ladell AJM 

PROVIDER: S-EPMC12698607 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature