Predictive value of peripheral blood CD4⁺ T and NK cells on efficacy and long-term survival in advanced HCC patients receiving immunotherapy.

ABSTRACT:

Background

Early assessment of the efficacy of immune checkpoint inhibitor (ICI) therapy in advanced hepatocellular carcinoma (HCC) patients plays a crucial role. In this study, we systematically analyzed the predictive values of various lymphocyte subpopulations (CD4⁺ T, CD8⁺ T, and NK cells) at different time points of pretreatment (W0), 3 weeks (W3) and 6 weeks (W6) post-treatment and their relative changes compared to W0 for objective response (OR).

Materials and methods

We systematically reviewed the clinical data of these patients in our hospital. Logistic regression analyses were conducted to identify variables predicting OR. Cut-off values were determined by maximizing Youden index. Then, patients were stratified based on these cut-off values, a

SUBMITTER: Pan Z 

PROVIDER: S-EPMC12698629 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature