Presurgical molecular therapy for renal cell carcinoma with venous tumor thrombus: a systematic review and meta-analysis.

ABSTRACT:

Background

Presurgical molecular therapy (PMT) including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) showed various outcomes for renal cell carcinoma (RCC) with tumor thrombus (TT). We aimed to evaluate the impact of PMT on Mayo level or TT height and the treatment-related adverse events (AEs).

Methods

A systematic literature search was conducted in PubMed, Embase, Cochrane Library, and Web of Science up to June 2023 to identify relevant studies investigating the impact of PMT on RCC patients with TT. The literature investigating the impact of PMT on RCC patients with venous TT, whether followed by surgery or not, was included.

Results

Overall, 184 patients were enrolled in this study. 30.7% (95% CI, 17.6-43.8%, I² = 79%, p<0.0

SUBMITTER: Chen K 

PROVIDER: S-EPMC12698656 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature