Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis.

ABSTRACT:

Purpose

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterized by the dysfunction of cytotoxic T cells (CTLs) and natural killer (NK) cells. The status of these immune cells during persistent inflammation remains unclear. This study aimed to investigate the immune cell subsets, the exhaustion and activation status, and the cytotoxic functions of the CTLs and NK cells in adult HLH. Furthermore, the features of immune cells in patients with Epstein-Barr virus-associated HLH (EBV-HLH) before and after treatment with programmed death-1 (PD-1) inhibitors were also analyzed.

Methods

Flow cytometry was utilized to evaluate the immune cell features in 75 patients with adult HLH.

Results

This study observed skewed immune cell subsets, along with

SUBMITTER: Qin Y 

PROVIDER: S-EPMC12698659 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature