Klebsiella ARO112 promotes microbiota recovery, pathobiont clearance and prevents inflammation in IBD mice.

ABSTRACT: Precise microbiota modulation towards improving immune function and metabolic homeostasis is a major goal in clinical research. It is also critical for reducing pathogen invasion or pathobiont expansion, contributors to epidemic Inflammatory Bowel Diseases (IBD), where recurrent antibiotic treatments often exacerbate microbiota imbalances. Within the thousands of strains of a natural gut microbiota, we previously identified a specific Klebsiella strain, ARO112, capable of promoting resistance to, and clearance of, pathogenic Enterobacteriaceae. Here, we assess its therapeutic potential using a comprehensive genomic and phenotypic analysis and experiments in mouse models of IBD. We demonstrate that ARO112 not only exhibits a safety profile comparable to the widely used probiotic Escherichia

SUBMITTER: Cabral V 

PROVIDER: S-EPMC12698716 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature