Diabetes duration, glycemic control, and risk of stroke and stroke subtypes: a nationwide prospective cohort study.

ABSTRACT: To evaluate the relationship of diabetes duration and glycemic control with risk of stroke and its major subtypes using data from the UK Biobank, a large population-based cohort of UK adults. We included 23,401 UK adult residents with diabetes who had no known stroke at baseline (2006-2010). Diabetes duration was self-reported and glycemic control was assessed by glycated hemoglobin (HbA1c) levels. Their associations with incident stroke were assessed using multivariate Cox models. During a median follow-up of 11.6 years, 982 incident cases of stroke were identified. A longer diabetes duration was associated with higher risk of total stroke, ischemic stroke (IS), and hemorrhagic stroke (HS) (≥ 15 vs. <5 years: HRs [95% CI] were 1.81 [1.50, 2.19], 1.80 [1.47, 2.20], and 2.17 [1.46, 3.23], r

SUBMITTER: Gao X 

PROVIDER: S-EPMC12698719 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature