Two-year decline in performance on the Cerebellar Cognitive Affective Syndrome Scale in spinocerebellar ataxias.

ABSTRACT:

Background and objectives

Cognitive deficits are observed in a subset of individuals with spinocerebellar ataxias (SCAs); however, there is limited research on the longitudinal trajectory of such deficits. We investigated longitudinal cognitive performance amongst individuals with SCAs relative to controls, and the relationship of change in cognitive performance with change in self-reported function.

Methods

Individuals with symptomatic SCA1, SCA2, SCA3, and SCA6 as well as unaffected controls were administered the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S) at yearly intervals for up to two years. Participants with SCA self-reported day-to-day cognitive and motor function via annual completion of the Patient-Reported Outcome Measure of Ataxia.

Results

Sign

SUBMITTER: Selvadurai LP 

PROVIDER: S-EPMC12698727 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature