A Comprehensive Design-to-skin Pipeline to Fabricate Polymeric Microneedles Using Ultrahigh-resolution 3D Printing.

ABSTRACT:

Objective

Microneedle technologies have emerged as a promising approach to improve intradermal drug delivery. This study presents a comprehensive workflow for fabricating polymeric microneedle arrays utilising ultrahigh-resolution 3-dimensional (3D) printing and silicone mould fabrication.

Methods

In this work, an extensive toolbox with over 75 distinct microneedle designs was created and sequentially fabricated from acryl using our workflow based on ultrahigh-resolution 3D printing.

Results

The microneedle design parameters included obelisk and cone-like shapes, various lengths, base and tip diameters, and different densities. We systematically assessed the optimal design parameters for effective penetration of ex vivo human skin explants.

Conclusion

Our workf

SUBMITTER: La Malfa F 

PROVIDER: S-EPMC12698738 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature