Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC.

ABSTRACT: PURPOSE RETINOBLASTOMA L: (RB1) mutations frequently emerge as late subclonal events in advanced prostate cancer (PCa), driving inevitable recurrence and therapy resistance. Therapy-induced senescence (TIS) could promote metastasis at a late stage. However, the underlying mechanisms and therapeutic approaches for decetaxel-induced senescence (DIS) in RB1-deficient castration-resistant prostate cancer (CRPC) remain poorly understood.

Methods

We systematically evaluated the association between RB1 expression and tumor malignancy using TCGA-PRAD data and clinical prostate cancer samples. Multiple CRPC models were established, including RM-1 C57BL/6 and PC-3 BALB/c-nu mouse models, as well as human PC-3 and 22RV1 cells to uncover the double-edged nature of DIS. Subsequently, RNA sequenc

SUBMITTER: Su H 

PROVIDER: S-EPMC12698756 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature