Serum iron levels as a risk factor for Osteoporosis-Related pathological fractures.

ABSTRACT:

Background

Osteoporosis is a prevalent bone disease characterized by decreased bone mass and deterioration of bone microstructure, leading to an increased risk of fractures. Pathological fractures, particularly in postmenopausal women, are a severe complication of osteoporosis. This study investigates the potential molecular role of micronutrients, particularly iron, in osteoporosis and its association with pathological fractures.

Methods

We performed a Mendelian randomization (MR) analysis using genome-wide association study (GWAS) summary data to explore the relationship between 15 trace elements (including iron, calcium, copper, and vitamins) and osteoporosis-related outcomes. Outcome data were obtained from the FinnGen database. The inverse-variance weighted (IVW) method

SUBMITTER: Lin S 

PROVIDER: S-EPMC12698794 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature