ST6GAL1-mediated sialylation inhibits the antitumor immune response in colorectal cancer.

ABSTRACT:

Purpose

Interferon gamma (IFNG) directly affects the antitumor immune response. ST6-β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) is also positively correlated with poor prognosis for colorectal cancer (CRC). we performed some works to exploreexplored the underlying mechanism to further understand immune escape in colorectal cancer (CRC).

Methods

First, we used clinical samples to confirm the relationship between ST6GAL1 and CRC. Afterward, we constructed overexpression/knockdown cell lines and performed bulk RNA sequencing, kinase phosphorylation chip, mass spectrometry, and in vitro and in vivo assays to explore the mechanism regulated by ST6GAL1. Finally, we verified the mechanism by performing immunoprecipitation and immunofluorescence (IF) staining.

Results

S

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12698818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature