Tumoral ALOX5 mediated arachidonic acid metabolism regulates immune response in non-small cell lung cancer.

ABSTRACT:

Purpose

Tumor cells reprogram their fatty acid metabolism to meet the demands for their rapid proliferation. However, the interplay between fatty acid metabolism and the tumor microenvironment (TME) in lung cancer remains poorly defined. This study aims to elucidate how arachidonic acid (AA) metabolism, specifically via the enzyme 5-lipoxygenase (ALOX5), modulates anti-tumor immunity in non-small cell lung cancer (NSCLC).

Methods

Data from public transcriptomic datasets were analyzed to identify differentially expressed and immune regulatory fatty acid metabolism-related genes in NSCLC. Spatial correlation between ALOX5 expression and CD8⁺ T cell infiltration was assessed via immunofluorescence. Functional impacts of ALOX5 on tumor growth, immune recruitment, and immunothera

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12698827 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature