Spatio-temporal kinetics of patients' CAR-T cells in blood and serous cavity effusion: real-world clinical insights.

ABSTRACT:

Background

Chimeric antigen receptor (CAR) T cells have long been regarded as living drugs, those activation, diffusion, and expansion influence the clinical efficacy. Dynamic monitoring of CAR-T cells in vivo is crucial for understanding their biodistribution and optimizing therapeutic outcomes. However, due to the challenges in sampling tissue-resident CAR-T cells from patients, limited data have been reported on their spatial and temporal distribution.

Methods

This study enrolled 43 patients with haematological malignancies receiving CAR-T cell therapy. CAR copy numbers in the peripheral blood (PB) and serous cavity effusion (SCE) were sequentially quantified and analysed.

Results

High expansion of CAR-T cells in PB was associated with subsequent expansion in SCE.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12698831 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature