Do cognitive tests capture symptoms that matter to people with Huntington's disease?

ABSTRACT: The Huntington's Disease Cognitive Assessment Battery (HD-CAB) is frequently used in clinical trials; however, it is unclear whether the HD-CAB captures meaningful symptoms from patients' perspectives. We aimed to explore whether HD-CAB tests are considered meaningful to people with Huntington's disease (HD) by mapping them to relevant symptoms and impacts. Eighteen people with HD before and after clinical motor diagnosis completed a semi-structured interview with symptom mapping to hierarchically rank the importance and bothersomeness of cognitive symptoms and discussed the relevance of each test to meaningful symptoms. Reflexive Thematic Analysis (RTA) was used to explore participant perceptions of the relevance of HD-CAB tests for assessing disease progression. Content coding was used t

SUBMITTER: Roiboit CM 

PROVIDER: S-EPMC12698843 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature