Associations between negative symptoms and thermal pain perception in bipolar I disorder.

ABSTRACT:

Background

There is emerging evidence that negative symptoms are a source of functional impairment for individuals with bipolar I disorder (BD). Patients with BD may also demonstrate notable changes in the perception of pain. The objective of this preliminary study was to explore potential associations between negative symptom severity and pain perception (measured with quantitative sensory testing (QST)) in BD as well as identify neurobiological correlates of these two domains.

Results

In patients with BD (N = 24, 30.3 ± 9.4 years of age), the Clinical Assessment Interview for Negative Symptoms (CAINS) Total and CAINS Motivation and Pleasure (MAP) subscale scores were associated with cold pain detection thresholds (CAINS Total: ρ = -0.49, p_UNC = 0.02, p_FDR</

SUBMITTER: Vrolix L 

PROVIDER: S-EPMC12698911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature