Causal associations between circulating metabolites and risk of neuroblastoma: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

The current understanding of the relationship between circulating metabolites and neuroblastoma (NB) risk is insufficient. Herein, bidirectional Mendelian randomization (MR) studies were utilized to examine the potential causal associations of metabolites and the risk of NB.

Methods

Significant single-nucleotide polymorphisms (SNPs) associated with circulating metabolites were obtained from the genome-wide association study (GWAS) in the European population (N = 7824). Summary statistics for NB were aggregated from prior GWAS studies encompassing 1,627 patients and 3,254 cancer-free children. The causality was assessed primarily by inverse-variance weighted (IVW), along with MR-Egger regression, weighted median estimator, and weighted mode method.

Results

A

SUBMITTER: Wu H 

PROVIDER: S-EPMC12698917 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature