A Versatile Macroscale Platelet Membrane Coating: A Biomimetic Strategy to Balance Antithrombogenicity and Proendothelialization on Vascular Stents.

ABSTRACT: Vascular stents require biointerfaces that simultaneously prevent thrombosis and promote endothelialization, yet achieving a balance of these conflicting demands on a single surface remains a challenge. While cell membrane coatings have demonstrated biomimetic potential, their application to macroscale devices has been largely limited to unstable noncovalent nanoparticle-focused approaches, which suffer from disordered assembly and poor stability under physiological flow. In contrast, we introduce a platelet membrane armor strategy facilitated by epigallocatechin gallate (EGCG) cross-linking, creating a robust macroscale coating that integrates both antithrombogenicity and proendothelialization. This covalent stabilization, achieved through EGCG's unique chemistry, effectively anchors plat

SUBMITTER: An Y 

PROVIDER: S-EPMC12698931 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature