Exploring Nasal Structural-Microbial Interactions in Multiple Sclerosis-Associated Olfactory Impairment.

ABSTRACT:

Background

Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition, and superior turbinate volume in MS.

Methods

This single-center observational study included 42 patients with MS and 37 healthy controls (HC) in China. Olfactory function was evaluated using the University of Pennsylvania Smell Identification Test (UPSIT). Deep nasal microbiota profiles and MRI-based measurements of superior turbinate volume were analyzed.

Results

A reduced relative abundance of Prevotella buccalis (P. buccalis)

SUBMITTER: Gao Z 

PROVIDER: S-EPMC12698952 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature