Plasma p-tau181 as a Marker of Conversion to Alzheimer's Disease Dementia and Worsening in Cognitive Functions in Subjective Cognitive Decline and Mild Cognitive Impairment: A Longitudinal Study.

ABSTRACT:

Background

Plasma p-tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p-tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).

Methods

We consecutively enrolled 163 patients (50 SCD, 70 MCI, and 43 AD-demented (AD-d)), who underwent plasma p-tau181 analysis with the Simoa assay. Patients were classified according to the Revised Criteria of the Alzheimer's Association Workgroup as Core1+ or Core1- (based on amyloid-PET, CSF Aβ42/Aβ40, CSF p-tau181/Aβ42).

Results

Plasma p-tau181 levels were significantly influenced by Core1 status (B = 1.41, p < 0.001) and clinical d

SUBMITTER: Giacomucci G 

PROVIDER: S-EPMC12698954 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature