Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross-Sectional Study.

ABSTRACT:

Background

Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi-domain function and disability.

Methods

In this multicenter cross-sectional study, participants completed a survey covering 71 post-infection symptoms, distinguishing new-onset from worsening symptoms. We defined long COVID using the 2024 NASEM criteria. Logistic regression assessed long COVID odds. Linear and Poisson regression evaluated associations with function and disability.

Results

969 pwMSRD (82.5% female, mean age 51.8 years, 63.5% infected) and 1003 controls (79.4% female, mean age 45.2 years, 61.2% infe

SUBMITTER: Hu C 

PROVIDER: S-EPMC12698955 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature