Comparative efficacy of diverse therapeutic regimens for small intestinal bacterial overgrowth: a systematic network meta-analysis.

ABSTRACT:

Background

The management of small intestinal bacterial overgrowth (SIBO) involves a range of therapeutic options such as antibiotics, probiotics, and prokinetic agents, yet their comparative clinical efficacy remains poorly characterized.

Objective

To address this critical evidence gap, we systematically evaluated all empirically used treatment regimens through a network meta-analysis (NMA) of published randomized controlled trials (RCTs), with the goal of providing clearer guidance for therapeutic selection.

Design

We conducted a systematic review and NMA following established methodological standards for evidence synthesis.

Data sources and methods

Our comprehensive literature search covered PubMed/MEDLINE, Embase, and Web of Science from their inception thr

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12699006 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature