Volume kinetics of lactated Ringer's solution in adult horses.

ABSTRACT:

Background

Fluid therapy in horses is primarily empirical. Evidence-based quantification of the disposition of intravenous (IV) crystalloids used in clinical practice could enhance the effectiveness of fluid therapy.

Objectives

To determine the pharmacokinetics (i.e., volume kinetics: VK) and associated haemodynamic effects of IV lactated Ringer's solution (LRS) in adult euvolemic horses.

Study design

Unmasked multiple subjects, single baseline design.

Methods

Thirteen healthy, euvolemic adult female horses were administered an IV bolus of LRS and monitored over 4 h. Haemoglobin, albumin and haematocrit concentrations were used to generate VK parameter estimates through a non-linear mixed effects model and stepwise covariate testing. Cardiorespiratory effects,

SUBMITTER: Muir WW 

PROVIDER: S-EPMC12699107 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature