Antitumor Effects of Chemlali and Wild Olive Tree Extracts: Role in Cell Proliferation and Apoptosis in Prostate (PC3) and Breast (MDA-MB-231) Cancer Cell Lines.

ABSTRACT: Cancer remains a major global health challenge, requiring natural therapeutic solutions. Olive tree by-products, like leaves and pomace, are rich in bioactive phenolics with antioxidant and anticancer potential. This study explores the chemical composition and anticancer potential of the hexane fraction of olive leaf extracts and the dichloromethane fraction of olive pomace extracts from two Olea europaea varieties: e cultivated Chemlali (var. europaea) and the wild olive (var. sylvestris). GC-MS analysis identified stigmast-5-en-3-ol, erythrodiol, and phytol as the predominant compounds in wild olive leaf extracts, whereas Chemlali leaf extracts contained only the first two. Analysis of olive pomace extracts revealed four major compounds: coniferyl alcohol, glyceryl m

SUBMITTER: Bouazizi R 

PROVIDER: S-EPMC12699138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature