Comprehensive multi-omics mapping of immune perturbations in autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is increasingly recognized as a neurodevelopmental condition with systemic immunological involvement, yet the underlying immune mechanisms remain incompletely defined.

Aims

To delineate the peripheral immune landscape in ASD using integrated multi-omics profiling and to determine how immune and immunometabolic alterations relate to clinical severity.

Materials & methods

Circulating immune cells from individuals with ASD were profiled using multicolor flow cytometry, single-cell RNA sequencing, and bulk RNA sequencing. Plasma proteomic and metabolomic analyses were performed to identify immune-related and metabolic biomarkers. Immune features were evaluated for associations with clinical severity measures.

Results

Multi-

SUBMITTER: Yan C 

PROVIDER: S-EPMC12699144 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature