Investigating Metal and Fluorophore Controlled Intracellular Localization in Noble Metal Thiosemicarbazone Complexes.

ABSTRACT: Transition metal complexes have been widely utilized as cellular imaging tools. To impart organelle specificity, ligand architecture is usually modified to modulate properties like overall charge and lipophilicity. In many such designs, the metal identity and its intrinsic properties are often ignored. To address this gap, in this study, we explored the effects of changing the metal center on the localization patterns of isostructural complexes. To this end, we employed the thiosemicarbazone Dp44mT to synthesize coumarin-conjugated complexes of Au(III), Pt(II), and Pd(II). Although the metal centers in these compounds share a formal d⁸ configuration, they differ in properties such as ionic radius, charge density, and ligand exchange rates, which can affect their subcellular loca

SUBMITTER: Sheernaly N 

PROVIDER: S-EPMC12699179 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature