¹⁵N Reaction Monitoring at Low and Inhomogeneous Magnetic Fields Enabled by Hyperpolarization with Parahydrogen.

ABSTRACT: The combination of hyperpolarization methods with low and inhomogeneous fields promises to expand the application of nuclear magnetic resonance (NMR) to fields that nowadays are not standard. Reducing the magnetic field strengths and homogeneity requirements opens the door to a wide variety of magnet designs that can allow for monitoring chemical reactions in the benchtop or even larger reactors. In this work, we propose a method to monitor ¹⁵ N chemical reactions at low and inhomogeneous fields based on parahydrogen-induced polarization. The concept was demonstrated at a magnetic field of 66 mT and 81 ppm inhomogeneity. Specifically, we measured the conversion of ¹⁵N-boronobenzyl-2-styrylpyridinium (¹⁵N-BBSP) to ¹⁵N-2-styrylpyridin (¹⁵

SUBMITTER: Rodriguez GG 

PROVIDER: S-EPMC12699185 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature