An all-in-one workflow for emergency hippocampal-avoidance whole-brain radiotherapy in brain metastases, with optional online adaptive extension.

ABSTRACT:

Background

Brain metastases (BMs), among the most prevalent intracranial malignant tumors, frequently induce acute symptoms such as headaches and motor deficits due to elevated intracranial pressure. Although hippocampal-avoidance whole brain radiotherapy (HA-WBRT) has demonstrated superior preservation of cognitive function compared to standard WBRT-despite comparable intracranial progression-free survival and overall survival outcomes-its clinical application remains restricted by the complexity and time-intensive nature of conventional planning and delivery protocols. These limitations hinder its utility as an emergent intervention for patients requiring urgent symptom relief.

Purpose

To address this challenge, we developed a novel HA-WBRT-specific all-in-one (AIO) radiot

SUBMITTER: Peng H 

PROVIDER: S-EPMC12699192 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature