Postpartum haemorrhage in pregnant carriers of haemophilia and women with von Willebrand disease: a nationwide inpatient database study.

ABSTRACT:

Background

Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide. Previous studies have presented varying conclusions regarding the PPH risk in pregnant haemophilia carriers or women with von Willebrand disease (VWD). We aimed to evaluate PPH occurrence in this demographic using a nationwide inpatient database in Japan.

Methods

In this retrospective study, we identified women aged 15-49 years who gave birth while hospitalised between July 2010 and March 2021, using the Japanese Diagnosis Procedure Combination database. These pregnant women were categorised into three groups: the haemophilia, VWD, and control cohort groups. The assessed outcomes were PPH and interventions for bleeding. Multivariable logistic regression analyses were performed to assess

SUBMITTER: Ishida R 

PROVIDER: S-EPMC12699230 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature