KIF1B Regulates NLRP3-Mediated Pyroptosis in Asthma Progression.

ABSTRACT: Asthma is a chronic inflammatory respiratory disorder triggered by allergens or environmental pollutants, characterised by airway obstruction, increased airway resistance and breathing difficulties. Although substantial progress has been made in elucidating its pathophysiology, the molecular mechanisms underlying asthma progression remain incompletely understood, and no curative therapies are currently available. The present study explored the role of KIF1B (kinesin family member 1B) in asthma pathogenesis using integrated approaches involving human cohort datasets, in vitro airway epithelial cell models and an in vivo ovalbumin (OVA)-induced asthma mouse model. KIF1B knockdown and NLRP3 (NLR family pyrin domain-containing 3) overexpression assays were performed to delineate the molecular

SUBMITTER: Wang J 

PROVIDER: S-EPMC12699257 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature