Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.

ABSTRACT: Given the historical underrepresentation of autistic females in neuroscience research, few neuroimaging studies have directly compared females and males with autism spectrum disorders (ASD) to explore both sex-independent and -specific neural features. This study employed a sliding-window approach to construct dynamic functional connectivity and investigated sex similarities and differences in modular variability (nodal level), edge variability (edge level), and state variability (brain state level) in brain connectomes among individuals with and without ASD. Ninety-eight autistic individuals (49 female, 49 male; full-scale IQ ≥ 70) and 98 typically developing individuals (TD; 49 female, 49 male), matched on sex, age, and full-scale IQ, were selected from the Autism Brain Imaging Data Exch

SUBMITTER: Ma X 

PROVIDER: S-EPMC12699260 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature