Digital Biomarkers of Cytokine Release Syndrome: Scoping Review and Ontology Development of the Role and Relevance of Digital Measures Using a Mixed Methods Approach.

ABSTRACT:

Background

Advancements in cancer-targeted immunotherapies have transformed care, yet these therapies present a high likelihood of cytokine release syndrome (CRS), a potentially severe immune-related adverse event. The ability to identify CRS earlier could improve care by mitigating risks, widening patient access, and reducing the burden on patients, caregivers, and health care providers. Digital health technologies (DHTs) are promising for early CRS detection by enabling continuous measurement of vital signs before symptoms are detected through standard intermittent clinical assessments. While the number of studies is increasing, inconsistencies in the symptoms and measures strongly associated with CRS highlight the need for a comprehensive review to identify the most reliable and

SUBMITTER: Medberry CJ 

PROVIDER: S-EPMC12699293 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature