Association between fat-to-muscle ratio and diabetic kidney disease: a nationwide NHANES analysis with real-world validation.

ABSTRACT:

Background

Obesity and abnormal body composition are recognized contributors to diabetic kidney disease (DKD) development. The fat-to-muscle mass ratio (FMR), an indicator of body composition, remains insufficiently studied in relation to DKD risk.

Methods

This study was a nationwide cohort analysis utilizing data from eight National Health and Nutrition Examination Survey (NHANES) cycles. FMR was derived using dual-energy X-ray absorptiometry (DXA) and evaluated in both categorical and continuous forms. Given the cross-sectional design of NHANES for DKD status assessment, the association between FMR and DKD was analyzed as a prevalence association. Mortality outcomes were further evaluated via retrospective linkage to the National Death Index, forming a retrospective mortal

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12699349 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature