Economic Evaluation of Comprehensive Genomic Profiling in an Advanced Solid Cancer Population.

ABSTRACT:

Importance

Developments in genomic profiling introduced larger gene panels with decreasing sequencing costs. Although the feasibility of comprehensive genomic profiling (CGP) has been demonstrated, its health economic impact remains uncertain.

Objective

To provide insights into the costs related to clinical implementation of CGP-based advice in a large prospective cohort.

Design, setting, and participants

In this economic evaluation of a prospective Belgian multicenter observational study (Belgian Approach of Local Laboratory Extensive Tumor Testing [BALLETT]), a decision tree was designed to illustrate costs and outcomes adopting a diagnostic time horizon. The evaluation also included a future evaluation scenario comparing standard-of-care diagnostics with upfront CG

SUBMITTER: van Schaik LF 

PROVIDER: S-EPMC12699362 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature