β-caryolane derivatives as novel anti-colorectal cancer agents: synthesis and <i>in vitro</i> biological evaluation.

ABSTRACT: β-Caryolane derivatives possess a unique skeletal structure and a wide range of practical applications. Recent studies suggest that certain β-caryolane derivatives may exhibit enhanced anti-colorectal cancer activity compared to their natural parent compounds, β-caryolanol and β-caryophyllene (β-CP). However, the structural diversity of known β-caryolane derivatives remains limited, likely due to challenges in their synthesis. In this study, we systematically investigated, for the first time, the reactivity of three nucleophiles (sulfonamides, amides, and azide) with β-CP under acid catalysis. The corresponding β-caryolane-type products were successfully obtained in a single step. The azide-addition product further underwent click reactions with various alkynes to yield triazole derivative

SUBMITTER: Xu X 

PROVIDER: S-EPMC12699372 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature