Clinical Features and Outcomes of Pneumococcal Bacteremia in Children With Sickle Cell Disease in the Pneumococcal Conjugate Vaccine Era.

ABSTRACT:

Introduction

Children with sickle cell disease (SCD) are at higher risk for invasive infection with Streptococcus pneumoniae compared with the general pediatric population. Penicillin prophylaxis, pneumococcal conjugate (PCV), and polysaccharide vaccines (PPSV) have reduced but not eliminated the risk of pneumococcal bacteremia.

Methods

A single institution cohort of children with SCD aged <19 years was reviewed over the 14-year period since PCV13 licensure (January 2010-December 2023) to identify and characterize the clinical features and outcomes of S. pneumoniae bacteremia, including serotypes and antibiotic susceptibility.

Results

The cohort included 4356 children with SCD (24,076 person-years). Thirty-eight patients with pneumococcal bacteremia were identified (3

SUBMITTER: Yee ME 

PROVIDER: S-EPMC12699443 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature