Opportunities to Avoid Invasive Cancer by Diagnosis and Interception of Preneoplastic Lesions and Cancer Risk Conditions.

ABSTRACT:

Background

Preneoplastic lesions (PNL) represent a state intermediate between normal cells and invasive cancer. Individuals diagnosed with PNL are at increased risk of developing invasive cancer and represent a unique risk group. We estimated the proportion of invasive cancer that could be intercepted at multiple anatomic sites in individuals with PNL.

Methods

Using a literature survey of the prevalence, latency, and probability of progression of PNL to invasive cancer, we undertook a sensitivity analysis across proportions of invasive cancer from 5% to 95% that could be intercepted in a cohort of 100,000 individuals that would be avoided if PNL interception was successful. To calculate the number of avoidable invasive cancers, we used data that represent population-based, h

SUBMITTER: Pradhan P 

PROVIDER: S-EPMC12699482 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature