Investigating the causal role of circulating metabolites in major depressive disorder.

ABSTRACT:

Background

Metabolic dysregulation has been implicated in major depressive disorder (MDD).

Aims

We aimed to explore the potential role of plasma metabolites in MDD.

Methods

We conducted Mendelian randomisation (MR) analysis to evaluate the causal effects of 871 circulating metabolites on MDD, using the Genome-Wide Association Studies datasets of MDD (N=1 035 760) and metabolites (N=8299). Bayesian colocalisation and druggability analyses were employed to identify genetic variants contributing to both MDD and levels of metabolites in plasma and to pinpoint metabolites with therapeutic potential, respectively.

Results

MR analysis identified 11 metabolites associated with MDD (false discovery rate<0.05). Eight metabolites, including arachidonate (20:4n6) (odds rat

SUBMITTER: Fu L 

PROVIDER: S-EPMC12699549 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature