Association of systemic corticosteroids and clinical outcomes in children hospitalised with severe orbital infections.

ABSTRACT:

Objectives

To evaluate the association between corticosteroid use and clinical outcomes in children hospitalised with severe orbital infections, and to describe practice patterns of systemic corticosteroid use.

Design

Multi-site observational cohort study using hospital data from 2009 to 2018.

Setting

Canadian children's hospitals (7) and community hospitals (3).

Patients

Children 2 months and 18 years hospitalised with severe orbital infections.

Interventions

Systemic corticosteroids at any time MAIN OUTCOME MEASURES: Length of hospital stay and surgical intervention using time-to-event Cox proportional hazards multivariable regression models to account for potential differences in timing of corticosteroid use (early, ≤24 hours or late, >24 hours after

SUBMITTER: Gonsalves CL 

PROVIDER: S-EPMC12699578 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature