Association of blood pressure control with atrial and ventricular ectopy in SPRINT.

ABSTRACT:

Background

Previous epidemiological studies demonstrated that premature atrial contractions (PACs) and premature ventricular contractions (PVCs) detected by single 12-lead ECGs can predict incident cardiovascular disease and death. The determinants of cardiac ectopy remain unknown, with some evidence that hypertension may contribute.

Objective

To determine if intensive blood pressure (BP) control reduces the incidence of cardiac ectopy.

Methods

We performed a post-hoc analysis of the Systolic Blood Pressure Intervention trial, which randomised hypertensive participants to standard treatment (BP target <140 mm Hg) or intensive treatment (<120 mm Hg) with ECGs obtained at baseline, 2 years, 4 years and 5 years. The primary outcomes were incidence of ectopy (PACs or PVCs

SUBMITTER: Pundi K 

PROVIDER: S-EPMC12699581 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature