International evaluation of the SEIZUre Risk in Encephalitis (SEIZURE) score for predicting acute seizure risk.

ABSTRACT:

Objective

Encephalitis is brain parenchyma inflammation, frequently resulting in seizures which worsens outcomes. Early anti-seizure medication could improve outcomes but requires identifying patients at greatest risk of acute seizures. The SEIZURE (SEIZUre Risk in Encephalitis) score was developed in UK cohorts to stratify patients by acute seizure risk. A 'basic score' used Glasgow Coma Scale (GCS), fever and age; the 'advanced score' added aetiology. This study aimed to evaluate the score internationally to determine its global applicability.

Design

Patients were retrospectively analysed regionally, and by country, in this international evaluation study. Univariate analysis was conducted between patients who did and did not have inpatient seizures, followed by multivariab

SUBMITTER: Hughes T 

PROVIDER: S-EPMC12699598 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature