Multifrequency MR elastography for grading inflammation in metabolic dysfunction-associated steatotic liver disease: a pilot study.

ABSTRACT:

Background

Noninvasive grading of liver inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD) remains an unmet clinical need.

Purpose

To evaluate the diagnostic performance of multifrequency MR elastography (MMRE) for grading liver inflammation and diagnosing metabolic dysfunction-associated steatohepatitis (MASH).

Materials and methods

In this prospective, single-site study, participants underwent MMRE at 30, 40, and 60 Hz on a 3T system. Multifrequency dispersion coefficient (α), storage modulus ( G' ), loss modulus ( G" ), and magnitude of the shear modulus ( |G*| ) were computed. The reference standard was histopathological analysis of needle biopsy specimens. The MASLD activity score was computed to assign MASH status. Univariate and mu

SUBMITTER: Baradaran Najar A 

PROVIDER: S-EPMC12699651 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature