Arecoline upregulates CD155 expression to facilitate immune evasion in oral squamous cell carcinoma.

ABSTRACT:

Background

Areca nut is the fourth most addictive substance worldwide and is a known Group 1 carcinogen. Chronic areca nut chewing has been strongly associated with the development of oral squamous cell carcinoma (OSCC), although the underlying carcinogenic mechanisms remain unclear.

Methods

Employing spatial multiomics technology, we recently mapped the immune microenvironment of areca nut-associated OSCC and identified a marked upregulation of the immune checkpoint molecule CD155 in these tumors. Further quantitative reverse transcription-PCR, western blotting, immunofluorescence, animal experiments, etc, explored and verified the reasons for the upregulation of CD155 caused by arecoline and the results of immune escape in OSCC.

Results

The investigation revealed th

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12699678 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature