Aberrant lipid metabolism reshapes the immune landscape in bone metastasis of nasopharyngeal carcinoma.

ABSTRACT:

Background

Bone metastasis (BM) drives therapeutic resistance and mortality in nasopharyngeal carcinoma (NPC). Tumor metabolites are crucial for NPC metastasis; however, the mechanisms by which these metabolites synergistically alter the immune microenvironment to promote BM remain unclear.

Methods

In this study, limited immune infiltration was observed in the NPC BM tumor microenvironment. Multiomics analysis has identified sphingosine kinase 1 (SPHK1) as a pivotal mediator driving BM and immune evasion in NPC, orchestrating the production of 1-phosphorylated sphingosine (S1P), which is critical for NPC pathogenesis.

Results

The aberrant buildup of lipid metabolites, along with immune microenvironment shifts, serves as a critical driver of NPC BM. Mechanistically, S1

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12699725 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature