Efficacy and safety of urate-lowering therapies in asymptomatic hyperuricaemia: a systematic review and network meta-analysis of key clinical outcomes.

ABSTRACT:

Objective

Asymptomatic hyperuricaemia (AH) is an independent risk factor for chronic kidney disease, cardiovascular events, and metabolic disorders. However, controversies persist regarding the clinical use of urate-lowering therapies (ULTs). This study employs a network meta-analysis (NMA) to systematically evaluate the efficacy and safety of ULTs in AH across seven key endpoints: serum uric acid (SUA), estimated glomerular filtration rate (eGFR), high-sensitivity C-reactive protein (hs-CRP), systolic blood pressure (SBP), major adverse cardiovascular events (MACE), composite renal events (CREs) and drug-induced liver injury (DILI). The findings aim to inform clinical decision-making.

Method

Four databases were systematically searched from their inception to March 2025 for

SUBMITTER: Yi Y 

PROVIDER: S-EPMC12699751 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature