Efficacy of opioid-free anesthesia in reducing postoperative adverse events for thoracoscopic pulmonary surgery: a randomized controlled trial.

ABSTRACT:

Background

This study compared the effects of opiate-free anesthesia (OFA) using thoracic paravertebral block combined with dexmedetomidine versus traditional anesthesia with sufentanil and remifentanil on postoperative adverse reactions after thoracoscopic lung surgery.

Methods

A prospective, randomized, double-blind trial included 97 patients(49 in OFA group,48 in S group).All received preoperative thoracic paravertebral block.The primary outcome was the incidence of opioid-related adverse reactions (hypoxemia, hypotension, nausea, vomiting, dizziness) at 2,4,6,24,and 48 h postoperatively.Secondary outcomes included intraoperative events, pain scores, opioid consumption, time to first flatus/defecation, and cardiovascular complications.

Results

At 2 h postoperativel

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12699814 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature